Identification of Hepatocyte Growth Factor Activator Inhibitor-1B as a Potential Physiological Inhibitor of Prostasin
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چکیده
منابع مشابه
Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1
Zebin Hong, Laura De Meulemeester, Annemarie Jacobi, Jan Skov Pedersen, J. Preben Morth, Peter A. Andreasen, and Jan K. Jensen From the Department of Molecular Biology and Genetics, Danish-Chinese Centre for Proteases and Cancer, Aarhus University, Gustav Wieds Vej 10C, 8000 Aarhus C, Denmark, the Department of Chemistry and iNANO Interdisciplinary Nanoscience Center, Aarhus University, 8000 Aa...
متن کاملHepatocyte growth factor activator inhibitor type 1 (Hai-1/Spint1) is a suppressor of intestinal tumorigenesis
Running title: HAI-1 suppresses intestinal tumorigenesis
متن کاملHepatocyte growth factor activator inhibitor type 1 is a suppressor of intestinal tumorigenesis.
Hepatocyte growth factor activator inhibitor type 1 (HAI-1/SPINT1) is a membrane-bound serine protease inhibitor expressed on the surface of epithelial cells. Although HAI-1/SPINT1 is abundantly expressed in the intestinal epithelium, its role in intestinal tumorigenesis is not known. In this study, we investigated the role of Hai-1/Spint1 in intestinal tumorigenesis using mouse models. The mem...
متن کاملHepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary.
HAI-1 [HGF (hepatocyte growth factor) activator inhibitor-1] is a Kunitz-type transmembrane serine protease inhibitor that forms inhibitor complexes with the trypsin-like serine protease, matriptase. HAI-1 is essential for mouse placental development and embryo survival and together with matriptase it is a key regulator of carcinogenesis. HAI-1 is expressed in polarized epithelial cells, which ...
متن کاملRegulation of hepatocyte growth factor activator inhibitor 2 by hypoxia in breast cancer.
PURPOSE To examine the in vitro regulation of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in breast cancer cells and the in vivo predictive role for the efficacy of chemoendocrine primary therapy in patients with breast cancer. MATERIALS AND METHODS HAI-2 regulation was studied in a panel of breast cancer cell lines comparing normoxia to hypoxia. The effect of HIF-1alpha RNAi ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m502119200